Title: Chemotherapy-induced structural changes in cerebral white matter and its correlation with impaired cognitive functioning in breast cancer patients
Authors: Deprez, Sabine ×
Amant, Frederic
Yigit, Refika
Porke, Kathleen
Verhoeven, Judith
Van den Stock, Jan
Smeets, Ann
Christiaens, Marie-Rose
Leemans, Alexander
Van Hecke, Wim
Vandenberghe, Joris
Vandenbulcke, Mathieu
Sunaert, Stefan #
Issue Date: Mar-2011
Publisher: Wiley-Liss
Series Title: Human Brain Mapping vol:32 issue:3 pages:480-493
Abstract: A subgroup of patients with breast cancer suffers from mild cognitive impairment after chemotherapy. To uncover the neural substrate of these mental complaints, we examined cerebral white matter (WM) integrity after chemotherapy using magnetic resonance diffusion tensor imaging (DTI) in combination with detailed cognitive assessment. Postchemotherapy breast cancer patients (n = 17) and matched healthy controls (n = 18) were recruited for DTI and neuropsychological testing, including the self-report cognitive failure questionnaire (CFQ). Differences in DTI WM integrity parameters [fractional anisotropy (FA) and mean diffusivity (MD)] between patients and healthy controls were assessed using a voxel-based two-sample-t-test. In comparison with healthy controls, the patient group demonstrated decreased FA in frontal and temporal WM tracts and increased MD in frontal WM. These differences were also confirmed when comparing this patient group with an additional control group of nonchemotherapy-treated breast cancer patients (n = 10). To address the heterogeneity observed in cognitive function after chemotherapy, we performed a voxel-based correlation analysis between FA values and individual neuropsychological test scores. Significant correlations of FA with neuropsychological tests covering the domain of attention and processing/psychomotor speed were found in temporal and parietal WM tracts. Furthermore, CFQ scores correlated negatively in frontal and parietal WM. These studies show that chemotherapy seems to affect WM integrity and that parameters derived from DTI have the required sensitivity to quantify neural changes related to chemotherapy-induced mild cognitive impairment. Hum Brain Mapp, 2010. (c) 2010 Wiley-Liss, Inc.
ISSN: 1065-9471
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiology
Youth Health (-)
Research Group Psychiatry
Multidisciplinary Breast Clinic Section (-)
Translational MRI (+)
Surgical Oncology
× corresponding author
# (joint) last author

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