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Title: Impurity profiling of acetylspiramycin by liquid chromatography-ion trap mass spectrometry
Authors: Wang, Ming-juan
Pendela, Murali
Jin, Shao-hong
Hoogmartens, Jos
Van Schepdael, Ann
Adams, Erwin # ×
Issue Date: Oct-2010
Publisher: Elsevier
Series Title: Journal of Chromatography A vol:1217 issue:42 pages:6531-6544
Abstract: Investigation of acetylspiramycin (ASPM) and its related substances was carried out using a reversed-phase liquid chromatography/tandem mass spectrometry method. The identification of impurities in the ASPM complex was performed with a quadrupole ion trap mass spectrometer, with an electrospray ionization (ESI) source in the positive ion mode which provides MSn capability. A total of 83 compounds were characterized in commercial samples, among which 31 impurities that had never been reported and 31 partially characterized impurities were deduced using the collision-induced dissociation (CID) spectra of major ASPM components as templates. Most of the major impurities arise from the starting materials and the synthesis process. This work provides very useful information for quality control of ASPM and evaluation of its synthesis process. (C) 2010 Elsevier B.V. All rights reserved.
URI: 
ISSN: 0021-9673
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
× corresponding author
# (joint) last author

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