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Title: Human herpesvirus 6 infection arrests cord blood mononuclear cells in G(2) phase of the cell cycle
Authors: De Bolle, Leen ×
Hatse, Sigrid
Verbeken, Eric
De Clercq, Erik
Naesens, Lieve #
Issue Date: Feb-2004
Series Title: FEBS Letters vol:560 issue:1-3 pages:25-9
Abstract: We here report that after infection with human herpesvirus 6A, human cord blood mononuclear cells accumulate in G(2)/M phase of the cell cycle. Experiments with foscarnet or ultraviolet (UV)-irradiated virus stocks pointed at an (immediate-)early, newly formed viral protein to be responsible for the arrest. At the molecular level, p53, cyclin B(1), cyclin A and tyrosine(15)-phosphorylated cdk1 accumulated after HHV-6A infection, indicating an arrest in G(2). However, no change was observed in the levels of downstream effectors of p53 in establishing a G(2) arrest, i.e. p21 and 14-3-3sigma. We thus conclude that the HHV-6A-induced G(2) arrest occurs independently of p53 accumulation.
URI: 
ISSN: 0014-5793
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
Translational Cell & Tissue Research
Laboratory of Experimental Oncology
× corresponding author
# (joint) last author

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