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Title: Primary peripheral PNET/Ewing's sarcoma of the dura: a clinicopathologic entity distinct from central PNET
Authors: Dedeurwaerdere, Franceska ×
Giannini, Caterina
Sciot, Raphael
Rubin, Brian P
Perilongo, Giorgio
Borghi, Laura
Ballotta, Maria Luisa
Cornips, Erwin
Demunter, Anouk
Maes, Brigitte
Dei Tos, Angelo P #
Issue Date: Jun-2002
Series Title: Modern Pathology vol:15 issue:6 pages:673-8
Abstract: We describe two cases of peripheral primitive neuroectodermal tumor-Ewing's sarcoma (PNET-ES) arising intracranially in the leptomeninges. Both tumors exhibited a primitive undifferentiated round-cell morphology. Immunohistochemical stains revealed strong membrane expression of CD99 in both cases. A t(11;22)(q24;q12) could be demonstrated with reverse transcriptase-polymerase chain reaction in one case, whereas fluorescence in situ hybridization analysis performed in the second case showed a rearrangement of the EWS gene. The occurrence of PNET-ES at this site is very unusual. Immunophenotypical as well as genetic analysis play a key role in the diagnosis and the distinction from central PNET.
ISSN: 0893-3952
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
× corresponding author
# (joint) last author

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