Title: Direct asymmetric syn-aldol reactions of linear aliphatic ketones with primary amino acid-derived diamines
Authors: Demuynck, Anneleen ×
Vanderleyden, Jozef
Sels, Bert #
Issue Date: 2010
Publisher: Wiley-VCH Verlag GmbH
Series Title: Advanced Synthesis & Catalysis vol:352 pages:2421-2426
Abstract: We have designed a novel class of chiral
diamine organocatalysts based on natural primary
amino acids that efficiently catalyze syn-selective
aldol reactions of challenging linear ketones, such
as 2-butanone, and aromatic aldehydes. In the presence
of trifluoroacetic acid (TFA) as Brønsted acid
and 2,4-dinitrophenol (DNP) as co-catalyst, synaldol
products have been obtained with excellent
enantioselectivities of up to> 99% ee.
ISSN: 1615-4150
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Centre of Microbial and Plant Genetics
Centre for Surface Chemistry and Catalysis
× corresponding author
# (joint) last author

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