Title: Prognostic Value of Pulmonary Doppler to Predict Response to Tracheal Occlusion in Fetuses with Congenital Diaphragmatic Hernia
Authors: Cruz-Martinez, Rogelio ×
Hernandez-Andrade, Edgar
Moreno-Alvarez, Oscar
Done, Elisa
Deprest, Jan
Gratacos, Eduard #
Issue Date: Sep-2011
Publisher: S. Karger
Series Title: Fetal Diagnosis and Therapy vol:29 issue:1 pages:18-24
Abstract: Pulmonary Doppler may play an important role in the prediction of survival and postnatal morbidity in fetuses with congenital diaphragmatic hernia treated with fetoscopic tracheal occlusion (FETO). Spectral Doppler indexes such as pulsatility index and peak early diastolic reversed flow could help to refine the selection of fetuses that might benefit from fetal therapy. When combined with lung-to-head ratio (LHR), these Doppler indices allow to discriminate cases with moderate-to-high survival rates from fetuses with extremely low chances to survive after FETO. In addition, they discriminate groups with a high or low risk of serious neonatal morbidity in surviving fetuses. After therapy, the combined evaluation of the relative increase of LHR with the increase in lung tissue perfusion by power Doppler seems to improve the prediction of fetal survival. In conclusion, while LHR remains the strongest predictive index, Doppler measurements allow to substantially improve the accuracy in the prediction of the chances of survival of fetuses with congenital diaphragmatic hernia treated with FETO.
ISSN: 1015-3837
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Foetal Medicine Section (-)
× corresponding author
# (joint) last author

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