Title: The yin and yang of intestinal epithelial cells in controlling dendritic cell function
Authors: Iliev, Iliyan D *
Matteoli, Gianluca *
Rescigno, Maria # ×
Issue Date: Oct-2007
Series Title: The Journal of experimental medicine vol:204 issue:10 pages:2253-7
Abstract: Recent work suggests that dendritic cells (DCs) in mucosal tissues are "educated" by intestinal epithelial cells (IECs) to suppress inflammation and promote immunological tolerance. After attack by pathogenic microorganisms, however, "non-educated" DCs are recruited from nearby areas, such as the dome of Peyer's patches (PPs) and the blood, to initiate inflammation and the ensuing immune response to the invader. Differential epithelial cell (EC) responses to commensals and pathogens may control these two tolorogenic and immunogenic functions of DCs.
ISSN: 0022-1007
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
* (joint) first author
× corresponding author
# (joint) last author

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