Title: The adhesion molecule L1 regulates transendothelial migration and trafficking of dendritic cells
Authors: Maddaluno, Luigi ×
Verbrugge, Sue Ellen
Martinoli, Chiara
Matteoli, Gianluca
Chiavelli, Andrea
Zeng, Yiping
Williams, Elizabeth D
Rescigno, Maria
Cavallaro, Ugo #
Issue Date: Mar-2009
Publisher: Rockefeller Institute for Medical Research
Series Title: Journal of Experimental Medicine vol:206 issue:3 pages:623-35
Abstract: The adhesion molecule L1, which is extensively characterized in the nervous system, is also expressed in dendritic cells (DCs), but its function there has remained elusive. To address this issue, we ablated L1 expression in DCs of conditional knockout mice. L1-deficient DCs were impaired in adhesion to and transmigration through monolayers of either lymphatic or blood vessel endothelial cells, implicating L1 in transendothelial migration of DCs. In agreement with these findings, L1 was expressed in cutaneous DCs that migrated to draining lymph nodes, and its ablation reduced DC trafficking in vivo. Within the skin, L1 was found in Langerhans cells but not in dermal DCs, and L1 deficiency impaired Langerhans cell migration. Under inflammatory conditions, L1 also became expressed in vascular endothelium and enhanced transmigration of DCs, likely through L1 homophilic interactions. Our results implicate L1 in the regulation of DC trafficking and shed light on novel mechanisms underlying transendothelial migration of DCs. These observations might offer novel therapeutic perspectives for the treatment of certain immunological disorders.
ISSN: 0022-1007
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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