Title: [Use of intravenous polyclonal immunoglobulins in autoimmune and inflammatory disorders]
Authors: Graff-Dubois, Stéphanie ×
Sibéril, Sophie
Sri Ramulu, Sri Ramulu
Negi, Vir-Singh
Delignat, Sandrine
Mouthon, Luc
Lacroix-Desmazes, Sébastien
Kazatchkine, Michel D
Bayary, Jagadeesh
Kaveri, Srini V #
Issue Date: May-2007
Series Title: Transfusion clinique et biologique : journal de la Société française de transfusion sanguine vol:14 issue:1 pages:63-8
Abstract: Initially used for the treatment of immunodeficiencies, intravenous immunoglobulins (IVIg) have increasingly been used as immunomodulatory agent in autoimmune and inflammatory disorders. The mode of action of IVIg is enigmatic, probably involving Fc-dependent and/or F(ab')2-dependent non-exclusive mechanisms of action. IVIg broadly interacts with the different components of the immune system: cytokines, complement, Fc receptors and several cell surface immunocompetent molecules. IVIg also has an impact on effector functions of immune cells. These mechanisms of action of IVIg reflect the importance of natural antibodies in the maintenance of immune homeostasis. We discuss here the recent advances in the understanding of immunoregulatory effects of IVIg, and we pointed out the need of new strategies to overcome the predicted increasing worldwide shortage of IVIg.
ISSN: 1246-7820
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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