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Title: Intravenous immunoglobulin in autoimmune and inflammatory diseases: more than mere transfer of antibodies
Authors: Sibéril, Sophie ×
Sri Ramulu, Sri Ramulu
Negi, Vir-Singh
Ephrem, Amal
Misra, Namita
Delignat, Sandrine
Bayary, Jagadeesh
Lacroix-Desmazes, Sébastien
Kazatchkine, Michel D
Kaveri, Srini V #
Issue Date: Aug-2007
Series Title: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis vol:37 issue:1 pages:103-7
Abstract: Initially used for the treatment of immunodeficiencies, intravenous immunoglobulin (IVIg) has increasingly been used as an immunomodulatory agent in immune thrombocytopenic purpura, autoimmune neuropathies, systemic lupus erythematosus, myasthenia gravis, Guillain-Barré syndrome, and Kawasaki disease. Although IVIg benefits have been reported in many autoimmune and systemic inflammatory diseases, its mechanisms of immunomodulation are not fully understood and probably involve Fc-dependent and/or F(ab')(2)-dependent mutually non-exclusive effects. These mechanisms of action of IVIg reflect the importance of natural antibodies in the maintenance of immune homeostasis. We discuss here the recent advances in the understanding of immunoregulatory effects of IVIg.
URI: 
ISSN: 1473-0502
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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