Title: Early time points perfusion imaging
Authors: Kwong, Kenneth K ×
Reese, Timothy G
Nelissen, Koen
Wu, Ona
Chan, Suk-Tak
Benner, Thomas
Mandeville, Joseph B
Foley, Mary
Vanduffel, Wim
Chesler, David A #
Issue Date: 15-Jan-2011
Publisher: Academic Press
Series Title: NeuroImage vol:54 issue:2 pages:1070-1082
Abstract: The aim was to investigate the feasibility of making relative cerebral blood flow (rCBF) maps from MR images acquired with short TR by measuring the initial arrival amount of Gd-DTPA evaluated within a time window before any contrast agent has a chance to leave the tissue. We named this rCBF measurement technique utilizing the early data points of the Gd-DTPA bolus the "early time points" method (ET), based on the hypothesis that early time point signals were proportional to rCBF. Simulation data were used successfully to examine the ideal behavior of ET while monkey's MRI results offered encouraging support to the utility of ET for rCBF calculation. A better brain coverage for ET could be obtained by applying the Simultaneous Echo Refocusing (SER) EPI technique. A recipe to run ET was presented, with attention paid to the noise problem around the time of arrival (TOA) of the contrast agent.
ISSN: 1053-8119
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Neurophysiology
× corresponding author
# (joint) last author

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