Title: Rotavirus disease and vaccination: impact on genotype diversity
Authors: Matthijnssens, Jelle ×
Bilcke, Joke
Ciarlet, Max
Martella, Vito
Bányai, Krisztián
Rahman, Mustafizur
Zeller, Mark
Beutels, Philippe
Van Damme, Pierre
Van Ranst, Marc #
Issue Date: Dec-2009
Publisher: Future Medicine Ltd.
Series Title: Future Microbiology vol:4 issue:10 pages:1303-1316
Abstract: Temporal and spatial fluctuations in the genotype distribution of human rotaviruses are continuously observed in surveillance studies. New genotypes, such as G9 and G12, have emerged and spread worldwide in a very short time span. In addition, reassortment events have the potential to contribute substantially to genetic diversity among human and animal rotaviruses. With the recent introduction of the two rotavirus vaccines, RotaTeq and Rotarix, in many countries, it appears that the total number of hospitalizations due to rotavirus infections is being reduced, at least in developed countries that implemented a universal immunization program. However, continued surveillance is warranted, especially regarding the long-term effects of the vaccines. No data analyses are available to clarify whether rotavirus vaccine introduction would allow other rotavirus P and G genotypes, which are not covered by the current vaccines, to emerge into the human population and fill the apparent gap. This kind of data analysis is essential, but its interpretation is hampered by natural and cyclical genotype fluctuations.
ISSN: 1746-0913
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
Faculty of Medicine - miscellaneous
× corresponding author
# (joint) last author

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