Title: Early outcome after lung transplantation from non-heart-beating donors is comparable to heart-beating donors
Authors: De Vleeschauwer, St√©phanie ×
Van Raemdonck, Dirk
Vanaudenaerde, Bart
Vos, Robin
Meers, Caroline Marie F
Wauters, Shana
Coosemans, Willy
Decaluwé, Herbert
De Leyn, Paul
Nafteux, Philippe
Dupont, Lieven
Lerut, Toni
Verleden, Geert #
Issue Date: Apr-2009
Publisher: Elsevier science inc
Series Title: Journal of heart and lung transplantation vol:28 issue:4 pages:380-387
Conference: ISHLT Annual Meeting and Scientific Sessions edition:29 location:Paris, France date:22-25 April 2009
Abstract: BACKGROUND: The use of non-heart-beating donors (NHBD) to overcome organ shortage is moving into the clinic. In 2007, 5 of 51 lung transplantations (LTx) in our center were performed with lungs from controlled NHBD. METHODS: Our aim was to describe these 5 NHBD LTx recipients and compare early outcome (<or= 6 months) with a cohort of 10 heart-beating donor (HBD) LTx recipients matched for age, gender, underlying disease, and time of surgery. Clinical outcomes were assessed, including ischemic times, gas exchange, primary graft dysfunction, time to extubation, time of discharge from intensive care unit/hospital, and pulmonary function. Airway and systematic inflammation were evaluated by bronchoalveolar lavage, total and differential cell counts, and plasma C-reactive protein levels, respectively. RESULTS: Early outcome in the NHBD group was comparable to the HBD group at the clinical and inflammatory level. The NHBD group showed a trend for earlier extubation (p = 0.054), greater increase in forced expiratory volume in 1 second (p = 0.054), and a significantly lower number of infections (p = 0.01). The NHBD group also had lower numbers of total cells (p = 0.04) and macrophages (p = 0.03) in bronchoalveolar lavage on day 21. CONCLUSIONS: Outcome after LTx in NHBD recipients is not inferior to HBD recipients during the first 6 months. Late results and effect on chronic rejection should be further awaited. Controlled NHBD may offer a valid source of lungs to overcome organ shortage in LTx.
ISSN: 1053-2498
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Thoracic Surgery
Laboratory of Abdominal Transplantation
Experimental Cardiac Surgery (-)
× corresponding author
# (joint) last author

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