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Title: Immunopathology of trachomatous conjunctivitis
Authors: el-Asrar, A M ×
van den Oord, Joost
Geboes, Karel
Missotten, Luc
Emarah, M H
Desmet, Valeer #
Issue Date: Apr-1989
Series Title: British Journal of Ophthalmology vol:73 issue:4 pages:276-82
Abstract: Upper palpebral conjunctival biopsy specimens obtained from eight patients with active trachoma were examined by routine histological and immunohistochemical methods. The epithelium expressed class I major histocompatibility complex (MHC) products throughout and class II MHC products in the superficial layers. The epithelial inflammatory infiltrate consisted of polymorphonuclear leucocytes, macrophages, T lymphocytes, and dendritic cells. In the underlying stroma the inflammatory infiltrate was organised as B lymphoid follicles, and there was also a diffuse infiltrate consisting of plasma cells and scattered B lymphoid cells, dendritic cells, T cells, macrophages, and polymorphonuclear leucocytes. Each type of cell has its special location in the tissue. Plasma cells were located on a subepithelial band and as a dense infiltrate round the acini of accessory lacrimal glands. IgA+ plasma cells outnumbered IgG+ cells, whereas IgM+ and IgE+ cells were few. Our data provide good evidence for the presence of both humoral and cell mediated immune responses and a possible role for autoimmune mechanisms in the conjunctival tissues of trachoma patients.
ISSN: 0007-1161
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
Alumni, Faculty of Medicine
Faculty of Medicine - miscellaneous
× corresponding author
# (joint) last author

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