Title: Measurement of sediment (MESED) and LC-MS-MS for cellular kinetics studies of STI-571 (Imatinib, Gleevec (R), Glivec (R)) in cells with different Pgp-170 expression
Authors: Prenen, Hans ×
Guetens, Gunther
van Oosterom, AT
De Boeck, Geert
Highley, MS
de Bruijn, EA #
Issue Date: Jun-2005
Publisher: Bentham science publ ltd
Series Title: Current analytical chemistry vol:1 issue:2 pages:121-127
Abstract: During long-term treatment with STI-571 (Gleevec(R), Glivec(R), Imatinib), it is possible that tumor cells change their expression of proteins in order La. to reduce their exposure to STI-571. This would eventually result in reduced activity. In order to evaluate this possibility, we have developed an analytical technique to determine intrinsic cellular concentrations of STI-571 in tumor cells which have been manipulated to generate lines with differential expression of the multi drug resistance protein Pgp-170. A high-speed isocratic high-performance liquid chromatographic method coupled to tandem mass spectrometry for the quantification of the new anticancer agent STI-571 in cultured tumor cells is described.
ISSN: 1573-4110
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
Laboratory of Experimental Oncology
Clinical Digestive Oncology (+)
× corresponding author
# (joint) last author

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