European Urological Review vol:4 issue:2 pages:25-29
Penile cancer is a rare malignancy with a prevalence of 1 in 100.000 men in developed countries. The conventional treatment of this cancer consisted of either partial or total penile amputation. These procedures are inherently disfiguring and have a profound impact on sexual and urinary functioning, body image and quality of life. After important histopathological analyses of the spreading pattern of penile cancer have been published, less radical and organ preserving surgical approaches have gained popularity. These organ-preserving techniques are cold-knife excision, laser surgery and Mohs micrographic surgery. Although due to the rareness of the disease no prospective trials are available, contemporary literature consists of multiple retrospective reports showing excellent oncological control with organ-preserving surgery for penile cancer. Local recurrence is a frequent issue in organ-preserving surgery, although it does not appear to impact disease specific survival. We reviewed the current literature on organ-preserving surgical techniques for penile cancer and provide an overview of background, indications and outcome of these treatment modalities.