Title: A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24
Authors: Goode, Ellen L ×
Chenevix-Trench, Georgia
Song, Honglin
Ramus, Susan J
Notaridou, Maria
Lawrenson, Kate
Widschwendter, Martin
Vierkant, Robert A
Larson, Melissa C
Kjaer, Susanne K
Birrer, Michael J
Berchuck, Andrew
Schildkraut, Joellen
Tomlinson, Ian
Kiemeney, Lambertus A
Cook, Linda S
Gronwald, Jacek
Garcia-Closas, Montserrat
Gore, Martin E
Campbell, Ian
Whittemore, Alice S
Sutphen, Rebecca
Phelan, Catherine
Anton-Culver, Hoda
Pearce, Celeste Leigh
Lambrechts, Diether
Rossing, Mary Anne
Chang-Claude, Jenny
Moysich, Kirsten B
Goodman, Marc T
Dörk, Thilo
Nevanlinna, Heli
Ness, Roberta B
Rafnar, Thorunn
Hogdall, Claus
Hogdall, Estrid
Fridley, Brooke L
Cunningham, Julie M
Sieh, Weiva
McGuire, Valerie
Godwin, Andrew K
Cramer, Daniel W
Hernandez, Dena
Levine, Douglas
Iversen, Edwin S
Palmieri, Rachel T
Houlston, Richard
van Altena, Anne M
Aben, Katja K H
Massuger, Leon F A G
Brooks-Wilson, Angela
Kelemen, Linda E
Jakubowska, Anna
Lubinski, Jan
Medrek, Krzysztof
Stafford, Anne
Easton, Douglas F
Tyrer, Jonathan
Bolton, Kelly L
Harrington, Patricia
Eccles, Diana
Chen, Ann
Molina, Ashley N
Davila, Barbara N
Arango, Hector
Tsai, Ya-Yu
Chen, Zhihua
Risch, Harvey A
McLaughlin, John
Narod, Steven A
Ziogas, Argyrios
Brewster, Wendy
Gentry-Maharaj, Aleksandra
Menon, Usha
Wu, Anna H
Stram, Daniel O
Pike, Malcolm C
Beesley, Jonathan
Webb, Penelope M
Chen, Xiaoqing
Ekici, Arif B
Thiel, Falk C
Beckmann, Matthias W
Yang, Hannah
Wentzensen, Nicolas
Lissowska, Jolanta
Fasching, Peter A
Despierre, Evelyn
Amant, Frédéric
Vergote, Ignace
Doherty, Jennifer
Hein, Rebecca
Wang-Gohrke, Shan
Lurie, Galina
Carney, Michael E
Thompson, Pamela J
Runnebaum, Ingo
Hillemanns, Peter
Dürst, Matthias
Antonenkova, Natalia
Bogdanova, Natalia
Leminen, Arto
Butzow, Ralf
Heikkinen, Tuomas
Stefansson, Kari
Sulem, Patrick
Besenbacher, Sören
Sellers, Thomas A
Gayther, Simon A
Pharoah, Paul D P #
Issue Date: Oct-2010
Publisher: Nature Publishing Group
Series Title: Nature Genetics vol:42 issue:10 pages:874-9
Abstract: Ovarian cancer accounts for more deaths than all other gynecological cancers combined. To identify common low-penetrance ovarian cancer susceptibility genes, we conducted a genome-wide association study of 507,094 SNPs in 1,768 individuals with ovarian cancer (cases) and 2,354 controls, with follow up of 21,955 SNPs in 4,162 cases and 4,810 controls, leading to the identification of a confirmed susceptibility locus at 9p22 (in BNC2). Here, we report on nine additional candidate loci (defined as having P ≤ 10⁻⁴) identified after stratifying cases by histology, which we genotyped in an additional 4,353 cases and 6,021 controls. We confirmed two new susceptibility loci with P ≤ 5 × 10⁻⁸ (8q24, P = 8.0 × 10⁻¹⁵ and 2q31, P = 3.8 × 10⁻¹⁴) and identified two additional loci that approached genome-wide significance (3q25, P = 7.1 × 10⁻⁸ and 17q21, P = 1.4 × 10⁻⁷). The associations of these loci with serous ovarian cancer were generally stronger than with other cancer subtypes. Analysis of HOXD1, MYC, TIPARP and SKAP1 at these loci and of BNC2 at 9p22 supports a functional role for these genes in ovarian cancer development.
ISSN: 1061-4036
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gynaecological Oncology
Vesalius Research Centre (-)
Laboratory of Translational Genetics (VIB-KU Leuven Center for Cancer Biology)
× corresponding author
# (joint) last author

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