Title: Common variants at 19p13 are associated with susceptibility to ovarian cancer
Authors: Bolton, Kelly L ×
Tyrer, Jonathan
Song, Honglin
Ramus, Susan J
Notaridou, Maria
Jones, Chris
Sher, Tanya
Gentry-Maharaj, Aleksandra
Wozniak, Eva
Tsai, Ya-Yu
Weidhaas, Joanne
Paik, Daniel
Van Den Berg, David J
Stram, Daniel O
Pearce, Celeste Leigh
Wu, Anna H
Brewster, Wendy
Anton-Culver, Hoda
Ziogas, Argyrios
Narod, Steven A
Levine, Douglas A
Kaye, Stanley B
Brown, Robert
Flanagan, James
Sieh, Weiva
McGuire, Valerie
Whittemore, Alice S
Campbell, Ian
Gore, Martin E
Lissowska, Jolanta
Yang, Hanna P
Medrek, Krzysztof
Gronwald, Jacek
Lubinski, Jan
Jakubowska, Anna
Cook, Linda S
Kelemen, Linda E
Brook-Wilson, Angela
Massuger, Leon F A G
Kiemeney, Lambertus A
Aben, Katja K H
van Altena, Anne M
Houlston, Richard
Tomlinson, Ian
Palmieri, Rachel T
Moorman, Patricia G
Schildkraut, Joellen
Iversen, Edwin S
Phelan, Catherine
Vierkant, Robert A
Cunningham, Julie M
Goode, Ellen L
Fridley, Brooke L
Kruger-Kjaer, Susan
Blaeker, Jan
Hogdall, Estrid
Hogdall, Claus
Gross, Jenny
Karlan, Beth Y
Ness, Roberta B
Edwards, Robert P
Odunsi, Kunle
Moyisch, Kirsten B
Baker, Julie A
Modugno, Francesmary
Heikkinenen, Tuomas
Butzow, Ralf
Nevanlinna, Heli
Leminen, Arto
Bogdanova, Natalia
Antonenkova, Natalia
Doerk, Thilo
Hillemanns, Peter
Dürst, Matthias
Runnebaum, Ingo
Thompson, Pamela J
Carney, Michael E
Goodman, Marc T
Lurie, Galina
Wang-Gohrke, Shan
Hein, Rebecca
Chang-Claude, Jenny
Rossing, Mary Anne
Cushing-Haugen, Kara L
Doherty, Jennifer
Chen, Chu
Rafnar, Thorunn
Besenbacher, Soren
Sulem, Patrick
Stefansson, Kari
Birrer, Michael J
Terry, Kathryn L
Hernandez, Dena
Cramer, Daniel W
Vergote, Ignace
Amant, Frédéric
Lambrechts, Diether
Despierre, Evelyn
Fasching, Peter A
Beckmann, Matthias W
Thiel, Falk C
Ekici, Arif B
Chen, Xiaoqing
Johnatty, Sharon E
Webb, Penelope M
Beesley, Jonathan
Chanock, Stephen
Garcia-Closas, Montserrat
Sellers, Tom
Easton, Douglas F
Berchuck, Andrew
Chenevix-Trench, Georgia
Pharoah, Paul D P
Gayther, Simon A #
Issue Date: Oct-2010
Publisher: Nature Publishing Group
Series Title: Nature Genetics vol:42 issue:10 pages:880-4
Abstract: Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5 × 10⁻⁴ and P = 6 × 10⁻⁴, respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3 × 10⁻⁹ and P = 4 × 10⁻¹¹, respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.
ISSN: 1061-4036
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gynaecological Oncology
Vesalius Research Centre (-)
Laboratory of Translational Genetics (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science