Evaluating knee function in patients treated with characterized chondrocyte implantation and microfracture, following an identical,standardized rehab protocol
Van Assche, Dieter Van Caspel, Danny Staes, Filip Bellemans, Johan Vanlauwe, Johan Saris, Daniel Luyten, Frank #
Osteoarthritis and Cartilage Vol. 15, Supplement B
International Cartilage Research Society edition:7th location:Warshaw, Poland date:sept 2007
Purpose: It may be expected that a two-step open surgery with characterized chondrocyte implantation (CCI) would be disadvantageous to the pace of knee function recovery compared to a one-step arthroscopic microfracture procedure. The objective was to assess the index knee function in patients following an identical, standardized rehab protocol, as part of a prospective randomized clinical trial comparing CCI to microfracture in treating symptomatic cartilage defects of the knee.
Methods and Materials: CCI (N=51) and microfracture (N=61) patients were assessed preoperatively and at 6, 9, and 12 months post operatively. Mobility (AROM), Anterior Laxity (with KT1000), Isokinetic Strength (by peak torque at 60°) and Functionality (with a single hop, the crossover triple hop and timed hop test) were evaluated. Of 112 evaluable patients, 100 completed the mobility tests, 85 the functional tests, 75 the strength tests and 65 of the patients completed the anterior laxity tests. Completion rate was equally divided among both groups.
Results: There were no significant differences in knee function between both treatment groups preoperatively. Also at 6, 9 and 12 months no significant differences were observed between treatment groups for all four tests, except at 9 months the difference for quadriceps strength for the microfracture group (Med =186) compared to the CCI group (Med= 144) was significant (p = 0,046). In general the knee function recovered at 12 months.
Conclusions: Under comparable rehabilitation conditions, the results demonstrate that the influence of the different surgical procedure was not significant on the function of the knee at 12 months.