Title: Lower vitamin D levels are associated with depression among community-dwelling European men
Authors: Lee, David M ×
Tajar, Abdelouahid
O'Neill, Terence W
O'Connor, Daryl B
Bartfai, Gyorgy
Boonen, Steven
Bouillon, Roger
Casanueva, Felipe F
Finn, Joseph D
Forti, Gianni
Giwercman, Aleksander
Huhtaniemi, Ilpo T
Kula, Krzysztof
Lean, Michael Ej
Punab, Margus
Silman, Alan J
Vanderschueren, Dirk
Wu, Frederick Cw
Pendleton, Neil #
Issue Date: Sep-2010
Publisher: Oxford University Press
Series Title: Journal of Psychopharmacology vol:25 issue:10 pages:1320-1328
Abstract: Low serum 25-hydroxyvitamin D (25(OH)D) and elevated parathyroid hormone (PTH) levels have been linked with depressive symptoms among adults in various clinical settings. Data in generally healthy, community-dwelling individuals remain inconclusive. We investigated whether depression was associated with 25(OH)D and/or PTH in a sample of middle-aged and older men (n = 3369; mean age 60 +/- 11) participating in the European Male Ageing Study, and whether any associations were explained by lifestyle and health factors. The Beck Depression Inventory-II (BDI-II) was used to screen for depression, and serum 25(OH)D and PTH levels measured by radioimmunoassay. Univariate analysis revealed that 25(OH)D levels were lower (p < 0.001) and PTH higher (p = 0.004) in people with depression. In age- and centre-adjusted linear regressions a higher BDI-II score was significantly associated with lower levels of 25(OH)D (p = 0.004). After adjustment for lifestyle and health factors this relationship was attenuated but remained significant (p = 0.01). Using multivariable logistic regression the odds for depression increased approximately 70% across decreasing 25(OH)D quartiles (ptrend = 0.04). There was no independent association between PTH and depression in any of the multivariable regressions. Our results reveal an inverse association between 25(OH)D levels and depression, largely independent of several lifestyle and health factors. Further studies are required to determine whether higher levels of vitamin D have an antidepressant effect in older adults.
ISSN: 0269-8811
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
Gerontology and Geriatrics
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science