Title: Cancer Cell Expression of Autotaxin Controls Bone Metastasis Formation in Mouse through Lysophosphatidic Acid-Dependent Activation of Osteoclasts
Authors: David, Marion ×
Wannecq, Estelle
Descotes, Francoise
Jansen, Silvia
Deux, Blandine
Ribeiro, Johnny
Serre, Claire-Marie
Gres, Sandra
Bendriss-Vermare, Nathalie
Bollen, Mathieu
Saez, Simone
Aoki, Junken
Saulnier-Blache, Jean-Sebastien
Clezardin, Philippe
Peyruchaud, Olivier #
Issue Date: 17-Mar-2010
Publisher: Public Library of Sciene
Series Title: PLoS One vol:5 issue:3 pages:-
Article number: e9741
Abstract: Background: Bone metastases are highly frequent complications of breast cancers. Current bone metastasis treatments using powerful anti-resorbtive agents are only palliative indicating that factors independent of bone resorption control bone metastasis progression. Autotaxin (ATX/NPP2) is a secreted protein with both oncogenic and pro-metastatic properties. Through its lysosphospholipase D (lysoPLD) activity, ATX controls the level of lysophosphatidic acid (LPA) in the blood. Platelet-derived LPA promotes the progression of osteolytic bone metastases of breast cancer cells. We asked whether ATX was involved in the bone metastasis process. We characterized the role of ATX in osteolytic bone metastasis formation by using genetically modified breast cancer cells exploited on different osteolytic bone metastasis mouse models.
ISSN: 1932-6203
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Biosignaling & Therapeutics
× corresponding author
# (joint) last author

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