Title: Synovial sarcoma of the larynx and hypopharynx
Authors: Dei Tos, A P ×
Dal Cin, Paola
Sciot, Raphael
Furlanetto, A
Da Mosto, M C
Giannini, C
Rinaldo, A
Ferlito, A #
Issue Date: Dec-1998
Series Title: Annals of Otology, Rhinology and Laryngology vol:107 issue:12 pages:1080-5
Abstract: Synovial sarcoma represents a mesenchymal malignancy of unknown histogenesis that most often occurs in the lower limbs of young adults. The head and neck region is a relatively rare location, in which the hypopharynx and larynx are, respectively, the most and least often affected anatomic sites. Histologically, synovial sarcomas are classified into monophasic and biphasic variants. Immunohistochemistry plays a major part in the differential diagnosis, enabling the demonstration of epithelial differentiation. Both monophasic and biphasic synovial sarcomas are characterized cytogenetically by the reciprocal translocation t(X;18)(p11.2;q11.2) between chromosomes X and 18. Two cases of synovial sarcoma arising in the larynx and in the hypopharynx and in which cytogenetic analysis detected a diagnostic t(X;18) chromosome aberration are reported here.
ISSN: 0003-4894
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
Clinical Genetics Section (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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