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Title: Oral administration of beta-1,3/1,6-glucan Macrogard fails to enhance the mucosal immune response following oral F4 fimbrial immunisation in gnotobiotic pigs
Authors: Stuyven, E ×
Van den Broeck, W
Nauwynck, H
Goddeeris, Bruno
Cox, E #
Issue Date: Oct-2010
Publisher: Elsevier
Series Title: Veterinary Immunology and Immunopathology vol:137 issue:3-4 pages:291-297
Abstract: In this study gnotobiotic animals were used to see if the F4 fimbrial antigen of F4ac+ Escherichia coli is as immunogenic as in conventional pigs. In addition, the adjuvant effect of beta-1,3/1,6-glucans was analysed for the first time in germ-free domestic animals. Oral F4 immunisation of F4 receptor positive (F4R(+)) piglets was able to induce a systemic and mucosal immune response as conventional pigs, although less pronounced. Nevertheless, an IgA response was observed in Peyer's patches and mesenteric lymph nodes. Moreover, a dose dependent effect was observed. Oral administration of beta-glucans for 5 weeks was not able to enhance this F4-specific immune response. The only effect of the beta-glucan treatment we observed was a significantly higher IL-1 alpha mRNA expression in the spleen. No significant changes in total serum antibody concentrations and in the volume of the ileal Peyer's patches were seen.
URI: 
ISSN: 0165-2427
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Division of Gene Technology (-)
× corresponding author
# (joint) last author

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