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Title: Alveolar soft-part sarcoma: evidence for its myogenic origin and for the involvement of 17q25
Authors: Sciot, Raphael ×
Dal Cin, Paola
De Vos, Rita
Van Damme, Boudewijn
De Wever, Ivo
Van den Berghe, Herman
Desmet, V J #
Issue Date: Nov-1993
Series Title: Histopathology vol:23 issue:5 pages:439-44
Abstract: A typical case of alveolar soft-part sarcoma was examined using ultrastructural, immunohistochemical and cytogenetic methods. Immunohistochemical stains were performed on frozen sections and showed strong desmin expression with the three anti-desmin antibodies used. In addition, the tumour cells were weakly positive for vimentin and myosin. Neural markers were negative. Chromosomal analysis showed consistent involvement of 17q25--an abnormality which has been reported in another alveolar soft-part sarcoma. The histogenesis of alveolar soft-part sarcoma is still debatable but our findings support a myogenic origin. The finding of an apparently identical chromosomal abnormality in two of three thus far examined cases of alveolar soft-part sarcoma is of interest and must await further confirmation, but it may result in the identification of a chromosomal marker for this enigmatic tumour and thus pave the way for further molecular elucidation.
ISSN: 0309-0167
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
Surgical Oncology
Clinical Genetics Section (-)
× corresponding author
# (joint) last author

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