ITEM METADATA RECORD
Title: Synaptic mitochondria in synaptic transmission and organization of vesicle pools in health and disease
Authors: Vos, Melissa *
Lauwers, Elsa *
Verstreken, Patrik # ×
Issue Date: 22-Sep-2010
Publisher: Frontiers Research Foundation
Series Title: Frontiers in Neuroscience vol:2 pages:1-10
Article number: 139
Abstract: Cell types rich in mitochondria, including neurons, display a high energy demand and a need for calcium buffering. The importance of mitochondria for proper neuronal function is stressed by the occurrence of neurological defects in patients suffering from a great variety of diseases caused by mutations in mitochondrial genes. Genetic and pharmacological evidence also reveal a role of these organelles in various aspects of neuronal physiology and in the pathogenesis of neurodegenerative disorders. Yet the mechanisms by which mitochondria can affect neurotransmission largely remain to be elucidated. In this review we focus on experimental data that suggest a critical function of synaptic mitochondria in the function and organization of synaptic vesicle pools, and in neurotransmitter release during intense neuronal activity. We discuss how calcium handling, ATP production and other mitochondrial mechanisms may influence synaptic vesicle pool organization and synaptic function. Given the link between synaptic mitochondrial function and neuronal communication, efforts towards better understanding mitochondrial biology may lead to novel therapeutic approaches of neurological disorders including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis and psychiatric disorders that are at least in part caused by mitochondrial deficits.
ISSN: 1662-453X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Laboratory of Neuronal Communication
* (joint) first author
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
fnsyn-02-00139.pdfOA article Published 1752KbAdobe PDFView/Open Request a copy

These files are only available to some KU Leuven Association staff members

 




All items in Lirias are protected by copyright, with all rights reserved.