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Title: Progressive intrahepatic cholestasis (Byler's disease): case report
Authors: De Vos, Rita ×
Peeters, C
Desmet, Valeer
Eggermont, Ephrem
Van Acker, K #
Issue Date: Dec-1975
Series Title: Gut vol:16 issue:12 pages:943-50
Abstract: This paper reports the case of a child in which the clinical and laboratory data indicate a progressive intrahepatic cholestasis of the type described as Byler's disease. The histological and histochemical findings suggest an intrahepatic cholestasis. Electron microscopy reveals interruptions of the bile canalicular membrane, which have been described as characteristic of this disease. A striking feature in the present case is the remarkable increase of microfilamentous structures in the pericanalicular ectoplasm and in the hepatocytic cytoplasm. The findings suggest a primary disturbance in bile acid secretion as the casue of cholestasis, entailing a hypertrophy of pericanalicular microfilaments which supposedly play a role in the final step of biliary secretion.
ISSN: 0017-5749
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
Faculty of Medicine - miscellaneous
× corresponding author
# (joint) last author

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