Title: Dabigatran inhibits staphyloccus aureus coagulase
Authors: Vanassche, Thomas
Verhaegen, Jozef
Peetermans, Willy
Hoylaerts, Marc
Verhamme, Peter # ×
Issue Date: Nov-2010
Publisher: American Society for Microbiology (ASM)
Series Title: Journal of Clinical Microbiology vol:48 issue:11 pages:4248-4250
Abstract: The ability of Staphylococcus aureus to clot plasma through conformational activation of prothrombin by staphylocoagulase is used to distinguish S. aureus from coagulase-negative staphylococci. We show that while the direct thrombin inhibitor dabigatran inhibits staphylocoagulase activity, the clinical use of dabigatran etexilate is not expected to interfere with direct tube coagulase testing.
ISSN: 0095-1137
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Vascular Biology
Laboratory for Clinical Infectious and Inflammatory Disorders
Laboratory of Clinical Bacteriology and Mycology
× corresponding author
# (joint) last author

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