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Title: Ethanol exhalation as a predictor of dilution hyponatraemia during endometrial ablation
Authors: Geerinckx, K ×
Vanderheyden, T
Meulemans, W
Verhamme, Peter
Hannon, H #
Issue Date: 1998
Publisher: Blackwell Pub.
Series Title: Gynaecological Endoscopy vol:7 issue:4 pages:193-201
Abstract: This study investigated the effectiveness of ethanol as an early indicator of resorption during transcervical endometrium resection (TCRE). Ethanol was added as a marker and exhaled alcohol concentrations were measured with an Alcomed test. Ninety-three patients underwent endometrial ablation under general anaesthesia and exhaled ethanol levels and blood sodium concentrations were monitored simultaneously every 3 minutes. In 23% of the cases the Alcomed test was the first indicator of absorption. Relevant changes in blood sodium concentrations appeared later in 9% of the cases and gives a positive Alcomed test. The predictive exhaled ethanol value for preventing the transurethral prostate resection (TUR) syndrome is 1.5 promille. A marked difference in fluid resorption during hysteroscopic myomectomy was observed (400-1000 mi during TCRE and myomectomy vs. 100-300 mi TCRE only). Of 83 TCRE patients, 23 had a positive Alcomed test. Ten patients underwent a hysteroscopic myomectomy. Sensitivity and specificity were determined for a decrease of more than 5 mmol l(-1) in blood sodium and for several ethanol levels. The sensitivity was 100% for an ethanol level of at least 0.05 promille. The specificity was 90.9% and the positive predictive value 41.7%. All patients with a decrease of more than 5 mmol l(-1) in blood sodium concentration were detected using a threshold of 0.05 promille exhaled ethanol and nine out of 10 patients with a blood sodium decrease of at least 5 mmol l(-1) also had an ethanol level of at least 0.05 promille. Unfortunately a positive Alcomed test has a poor prognostic value.
ISSN: 0962-1091
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Vascular Biology
Cardiology
× corresponding author
# (joint) last author

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