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Title: Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis
Authors: De Roock, Wendy ×
Claes, Bart
Bernasconi, David
De Schutter, Jef
Biesmans, Bart
Fountzilas, George
Kalogeras, Konstantine
Kotoula, Vassiliki
Papamichael, Demetris
Laurent-Puig, Pierre
Penault-Llorca, Frédérique
Rougier, Philippe
Vincenzi, Bruno
Santini, Daniele
Tonini, Giuseppe
Cappuzzo, Federico
Frattini, Milo
Molinari, Francesca
Saletti, Piercarlo
De Dosso, Sara
Martini, Miriam
Bardelli, Alberto
Siena, Salvatore
Sartore-Bianchi, Andrea
Tabernero, Josep
Macarulla, Teresa
Di Fiore, Frédéric
Oden Gangloff, Alice
Ciardiello, Fortunato
Pfeiffer, Per
Qvortrup, Camilla
Plato Hansen, Tine
Van Cutsem, Eric
Piessevaux, Hubert
Lambrechts, Diether
Delorenzi, Mauro
Tejpar, Sabine #
Issue Date: Aug-2010
Publisher: Lancet Pub. Group
Series Title: The Lancet Oncology vol:11 issue:8 pages:753-762
Abstract: Following the discovery that mutant KRAS is associated with resistance to anti-epidermal growth factor receptor (EGFR) antibodies, the tumours of patients with metastatic colorectal cancer are now profiled for seven KRAS mutations before receiving cetuximab or panitumumab. However, most patients with KRAS wild-type tumours still do not respond. We studied the effect of other downstream mutations on the efficacy of cetuximab in, to our knowledge, the largest cohort to date of patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab plus chemotherapy in the pre-KRAS selection era.
ISSN: 1470-2045
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
Department of Human Genetics - miscellaneous
Vesalius Research Centre (-)
Molecular Digestive Oncology (+)
Clinical Digestive Oncology (+)
Laboratory of Translational Genetics (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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