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Title: Diffusion-weighted magnetic resonance imaging allows noninvasive in vivo monitoring of the effects of combretastatin a-4 phosphate after repeated administration
Authors: Thoeny, Harriet C
De Keyzer, Frederik
Chen, Feng
Vandecaveye, Vincent
Verbeken, Eric
Ahmed, B
Sun, Xihe
Ni, Yicheng
Bosmans, Hilde
Hermans, Robert
Van Oosterom, Allan
Marchal, Guy
Landuyt, Willy # ×
Issue Date: Aug-2005
Publisher: Stockton Press
Series Title: Neoplasia vol:7 issue:8 pages:779-787
Abstract: The noninvasive assessment of anticancer treatment efficacy is very important for the improvement of therapeutic window. The purpose of the present study was to evaluate the antitumoral effects of the vascular targeting agent, combretastatin A-4 phosphate (CA-4-P), at selected time points after repeated intraperitoneal drug administrations (25 mg/kg), using diffusion-weighted magnetic resonance imaging (DW-MRI). The experiments were performed during an overall follow-up period of 3 weeks on WAG/Rij rats with subcutaneously growing rhabdomyosarcomas. Each animal served as its own baseline. The DW-MRI studies were quantified by calculating the apparent diffusion coefficient (ADC) for different low and high b-values to separate the effects on tumor vasculature and cellular integrity. The changes in ADC as well as the extent of necrosis development (proportional to the tumor volume), measured on the MR images, were of comparable magnitude after each treatment. All ADC values showed a significant decrease at 6 hours, followed by a significant increase at 2 days for various CA-4-P administrations. DW-MRI allowed us to monitor both reduction in perfusion and changes in the extent of tumor necrosis after CA-4-P injection. Repeated CA-4-P administration retains efficacy in rat rhabdomyosarcomas, with similar findings after each drug administration.
ISSN: 1522-8002
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiology
Translational Cell & Tissue Research
Department of Oncology - miscellaneous
Theragnostic Laboratory (+)
Translational MRI (+)
× corresponding author
# (joint) last author

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