Title: Beneficial effects of creatine supplementation in dystrophic patients
Authors: Louis, Magali ×
Lebacq, Jean
Poortmans, Jacques R
Belpaire-Dethiou, Marie-Claude
Devogelaer, Jean-Pierre
Van Hecke, Paul
Goubel, Francis
Francaux, Marc #
Issue Date: May-2003
Series Title: Muscle & nerve vol:27 issue:5 pages:604-10
Abstract: The effect of creatine (Cr) supplementation on muscle function and body composition of 12 boys with Duchenne muscular dystrophy and three with Becker dystrophy was evaluated by a randomized double-blind cross-over study (3 g Cr or maltodextrin daily for 3 months, with wash-out period of 2 months). After placebo, no change was observed in maximal voluntary contraction (MVC) and resistance to fatigue, whereas total joint stiffness (TJS) was increased by approximately 25% (P < 0.05). The patients receiving Cr did not show any change in TJS, improved MVC by 15% (P = 0.02), and almost doubled their resistance to fatigue (P < 0.001). In patients still independent of a wheelchair (n = 5), bone mineral density increased by 3% (P < 0.05), and urinary excretion of collagen type I cross-linking N-telopeptide declined to about one third (P < 0.001) after Cr. No adverse effect was observed. Thus, Cr may provide some symptomatic benefit in these patients.
ISSN: 0148-639X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biomedical MRI
× corresponding author
# (joint) last author

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