Title: Simultaneous study of karyotype and bone marrow histology in chronic myeloid leukemia with Ph1 chromsome
Authors: Michaux, J L ×
Van den Berghe, Herman
Rodhain, J
Sokal, G
David, Guido
Hulhoven, R #
Issue Date: 1975
Publisher: Editions Gallimard
Series Title: La Nouvelle Revue Française vol:15 issue:5 pages:575-88
Abstract: This study was devoted to the simultaneous examination of the karyotype and the bone marrow histology in 33 patients suffering from chronic myeloid leukemia with the Ph1 chromosome. Some patients were evaluated in the beginning of the disease, others after evolution and treatment and some at both times. Supplementary abnormalities of the karyotype occurred in some patients before any treatment, but in most after evolution and treatment. The abnormalities encountered consisted in hypodiploidies, modifications of chromosome structure and hyperdiploidies. The additional abnormalities of the karyotype were in the majority of the patients accompanied by a bone marrow histology characterized by more pronounced blastic infiltration and precollagen fibrosis and evidence of bone lesions. The picture realized by the karyotype and the bone marrow histology allows a better evaluation of the evolution and the prognosis is individual cases, especially of the likely hood of the acute blastic transformation.
ISSN: 0029-4802
Publication status: published
KU Leuven publication type: AT
Appears in Collections:Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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