Title: Chromosome abnormalities in acute promyelocytic leukemia (APL)
Authors: Van den Berghe, Herman ×
Louwagie, Andries
Broeckaert-Van Orshoven, A
David, Guido
Verwilghen, Robrecht
Michaux, J L
Sokal, G #
Issue Date: Feb-1979
Series Title: Cancer vol:43 issue:2 pages:558-62
Abstract: Sixteen patients, 15 adults and one child, with APL have been studied cytogenetically; 14 of these had an abnormal karyotype (87%). Eleven of these consistently showed a t(15;17)(q26;q22) structural anomaly, one patient showed a 47,+8 karyotype, one a rearrangement of chromosomes No. 15 and No. 17, apparently different from that in the other patients, and one a No. 17 deletion without a demonstrable translocation. as an additional chromosome change trisomy No. 8 was found in 5 cases and monosomy No. 7 in two. The t)15;17)(q26;q22) structural anomaly is highly characteristic of APL, is found in APL of children and adults, but it is apparently not associated with a clinically different form of APL.
ISSN: 0008-543X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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