Title: Pannexin channels in ATP release and beyond: An unexpected rendezvous at the endoplasmic reticulum
Authors: D'hondt, Catheleyne
Ponsaerts, Raf
De Smedt, Humbert
Vinken, Mathieu
De Vuyst, Elke
De Bock, Marijke
Wang, Nan
Rogiers, Vera
Leybaert, Luc
Himpens, Bernard
Bultynck, Geert # ×
Issue Date: Feb-2011
Publisher: Pergamon Press
Series Title: Cellular Signalling vol:23 issue:2 pages:305-316
Abstract: The pannexin (Panx) family of proteins, which is co-expressed with connexins (Cxs) in vertebrates, was found to be a new GJ-forming protein family related to invertebrate innexins. During the past ten years, different studies showed that Panxs mainly form hemichannels in the plasma membrane and mediate paracrine signalling by providing a flux pathway for ions such as Ca(2+), for ATP and perhaps for other compounds, in response to physiological and pathological stimuli. Although the physiological role of Panxs as a hemichannel was questioned, there is increasing evidence that Panx play a role in vasodilatation, initiation of inflammatory responses, ischemic death of neurons, epilepsy and in tumor suppression. Moreover, it is intriguing that Panxs may also function at the endoplasmic reticulum (ER) as intracellular Ca(2+)-leak channel and may be involved in ER-related functions. Although the physiological significance and meaning of such Panx-regulated intracellular Ca(2+) leak requires further exploration, this functional property places Panx at the centre of many physiological and pathophysiological processes, given the fundamental role of intracellular Ca(2+) homeostasis and dynamics in a plethora of physiological processes. In this review, we therefore want to focus on Panx as channels at the plasma membrane and at the ER membranes with a particular emphasis on the potential implications of the latter in intracellular Ca(2+) signalling.
ISSN: 0898-6568
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular and Cellular Signaling
× corresponding author
# (joint) last author

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