Title: Fitness differences associated with Pgi SNP genotypes in the Glanville fritillary butterfly (Melitaea cinxia)
Authors: Orsini, Luisa ×
Wheat, C W
Haag, C R
Kvist, J
Frilander, M J
Hanski, I #
Issue Date: Feb-2009
Publisher: Birkhäuser
Series Title: Journal of Evolutionary Biology vol:22 issue:2 pages:367-375
Abstract: Allozyme variation at the phosphoglucose isomerase (PGI) locus in the Glanville fritillary butterfly (Melitaea cinxia) is associated with variation in flight metabolic rate, dispersal rate, fecundity and local population growth rate. To map allozyme to DNA variation and to survey putative functional variation in genomic DNA, we cloned the coding sequence of Pgi and identified nonsynonymous variable sites that determine the most common allozyme alleles. We show that these single-nucleotide polymorphisms (SNPs) exhibit significant excess of heterozygotes in field-collected population samples as well as in laboratory crosses. This is in contrast to previous results for the same species in which other allozymes and SNPs were in Hardy-Weinberg equilibrium or exhibited an excess of homozygotes. Our results suggest that viability selection favours Pgi heterozygotes. Although this is consistent with direct overdominance at Pgi, we cannot exclude the possibility that heterozygote advantage is caused by the presence of one or more deleterious alleles at linked loci.
ISSN: 1010-061X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Aquatic Ecology and Evolutionary Biology (-)
× corresponding author
# (joint) last author

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