Title: Carcinoid heart disease: Case and literature review
Authors: Dumoulein, Michiel ×
Verslype, Chris
Van Cutsem, Eric
Meuris, Bart
Herijgers, Paul
Flameng, Willem
Herregods, Marie-Christine #
Issue Date: Apr-2010
Publisher: Acta cardiologica
Series Title: Acta cardiologica vol:65 issue:2 pages:261-264
Abstract: We present the case of a 69-year-old woman with a metastatic neuroendocrine tumour of the ileum and severe tricuspid valve regurgitation due to carcinoid valvulopathy. Carcinoid heart disease arises in the context of metastatic serotonin-producing neuroendocrine tumours and typically presents as structural and functional abnormalities of tricuspid (TV) or pulmonary valve (PV). Carcinoid heart disease arises from a low-grade neuroendocrine tumour derived from serotonin-producing enterochromaffin cells that reduces the mobility of the leaflets. Following the development of this type of heart failure, the prognosis is unfavourable and patients usually die as a result of heart failure and not because of the metastatic disease. Our patient was not considered a candidate for valvular surgery because of the progressive nature of the malignancy. However, surgical valve replacement is a therapeutic option that, although it has a significant mortality, needs to be considered in selected patients and leads to improvement in functional capacity and survival.
ISSN: 0001-5385
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Cardiology
Translational Research in GastroIntestinal Disorders
Experimental Cardiac Surgery (-)
Cardiac Surgery
Clinical Residents Medicine
Clinical Digestive Oncology (+)
× corresponding author
# (joint) last author

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