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Title: Covering all bases in HIV research: unveiling a hidden world of viral evolution
Authors: Vrancken, Bram ×
Lequime, Sébastian
Theys, Kristof
Lemey, Philippe #
Issue Date: Apr-2010
Publisher: Permanyer Publications
Series Title: AIDS Reviews vol:12 issue:2 pages:89-102
Abstract: The advent of next-generation sequencing technologies has greatly impacted genomic research by providing a means for increasing the amount of sequence information in a cost effective fashion. Among the major next-generation sequencing technologies, the Roche 454 platform has been widely adopted in HIV research. We discuss a broad range of applications of the 454 pyrosequencing platform in the HIV field, with a particular emphasis on antiretroviral therapy and virus-host interaction-related research. We also highlight some of the bioinformatics challenges, as well as advantages and potential limitations of this "deep" sequencing tool, and hint at future research applications.
URI: 
ISSN: 1139-6121
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
× corresponding author
# (joint) last author

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