Title: Microwave-assisted synthesis of a novel class of imidazolylthiazolidin-4-ones and evaluation of its biological activities
Authors: Modha, Sachinkumar
Mehta Pravinchandra, Vaibhav
Ermolat'ev, Denis
Balzarini, Jan
Van Hecke, Kristof
Van Meervelt, Luc
Van der Eycken, Erik # ×
Issue Date: Nov-2010
Publisher: ESCOM Science Publishers
Series Title: Molecular Diversity vol:14 pages:767-76
Abstract: The synthesis and biological activity of a hitherto unknown class of compounds, the imidazolylthiazolidin-4-ones, are described. A two-step procedure has been elaborated starting from our previously described 2-aminoimidazoles. The application of microwave irradiation has been proven to be beneficial for the condensation of the imine with mercaptoacetic acid leading to the formation of imidazolylthiazolidin-4-ones. None of the compounds showed antiviral activity at subtoxic concentrations. Several compounds displayed a moderate cytostatic activity. These data form the basis for further improvement of the potential antiproliferative activity of this class of compounds.
ISSN: 1381-1991
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
Chemistry - miscellaneous
Laboratory of Virology and Chemotherapy (Rega Institute)
Biochemistry, Molecular and Structural Biology Section
× corresponding author
# (joint) last author

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