Title: Transmission of drug-resistant HIV-1 is stabilizing in Europe
Authors: Vercauteren, Jurgen ×
Wensing, Annemarie M J
van de Vijver, David A M C
Albert, Jan
Balotta, Claudia
Hamouda, Osamah
Kücherer, Claudia
Struck, Daniel
Schmit, Jean-Claude
Asjö, Birgitta
Bruckova, Marie
Camacho, Ricardo J
Clotet, Bonaventura
Coughlan, Suzie
Grossman, Zehava
Horban, Andrzej
Korn, Klaus
Kostrikis, Leondios
Nielsen, Claus
Paraskevis, Dimitrios
Poljak, Mario
Puchhammer-Stöckl, Elisabeth
Riva, Chiara
Ruiz, Lidia
Salminen, Mika
Schuurman, Rob
Sonnerborg, Anders
Stanekova, Danica
Stanojevic, Maja
Vandamme, Anne-Mieke
Boucher, Charles A B #
Issue Date: Nov-2009
Publisher: Published by the University of Chicago Press for the Infectious Diseases Society of America
Series Title: The Journal of Infectious Diseases vol:200 issue:10 pages:1503-1508
Abstract: The SPREAD Programme investigated prospectively the time trend from September 2002 through December 2005 of transmitted drug resistance (TDR) among 2793 patients in 20 European countries and in Israel with newly diagnosed human immunodeficiency virus type 1 (HIV-1) infection. The overall prevalence of TDR was 8.4% (225 of 2687 patients; 95% confidence interval [CI], 7.4%-9.5%), the prevalence of nucleoside reverse-transcriptase inhibitor (NRTI) resistance was 4.7% (125 of 2687 patients; 95% CI, 3.9%-5.5%), the prevalence of nonucleoside reverse-transcriptase inhibitor (NNRTI) resistance was 2.3% (62 of 2687 patients; 95% CI, 1.8%-2.9%), and the prevalence of protease inhibitor (PI) resistance was 2.9% (79 of 2687 patients; 95% CI, 2.4%-3.6%). There was no time trend in the overall TDR or in NRTI resistance, but there was a statistically significant decrease in PI resistance (P = .04) and in NNRTI resistance after an initial increase (P = .02). We found that TDR appears to be stabilizing in Europe, consistent with recent reports of decreasing drug resistance and improved viral suppression in patients treated for HIV-1 infection.
ISSN: 0022-1899
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
× corresponding author
# (joint) last author

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