Title: A prospective randomised, open-labeled, trial comparing sirolimus-containing versus mTOR-inhibitor-free immunosuppression in patients undergoing liver transplantation for hepatocellular carcinoma
Authors: Schnitzbauer, Andreas A ×
Zuelke, Carl
Graeb, Christian
Rochon, Justine
Bilbao, Itxarone
Burra, Patrizia
de Jong, Koert P
Duvoux, Christophe
Kneteman, Norman M
Adam, Rene
Bechstein, Wolf O
Becker, Thomas
Beckebaum, Susanne
Chazouilleres, Olivier
Cillo, Umberto
Colledan, Michele
Faendrich, Fred
Gugenheim, Jean
Hauss, Johann P
Heise, Michael
Hidalgo, Ernest
Jamieson, Neville
Koenigsrainer, Alfred
Lamby, Philipp E
Lerut, Jan P
Makisalo, Heikki
Margreiter, Raimund
Mazzaferro, Vincenzo
Mutzbauer, Ingrid
Otto, Gerd
Pageaux, Georges-Philippe
Pinna, Antonio D
Pirenne, Jacques
Rizell, Magnus
Rossi, Giorgio
Rostaing, Lionel
Roy, Andre
Sanchez Turrion, Victor
Schmidt, Jan
Troisi, Roberto I
van Hoek, Bart
Valente, Umberto
Wolf, Philippe
Wolters, Heiner
Mirza, Darius F
Scholz, Tim
Steininger, Rudolf
Soderdahl, Gunnar
Strasser, Simone I
Jauch, Karl-Walter
Neuhaus, Peter
Schlitt, Hans J
Geissler, Edward K #
Issue Date: 11-May-2010
Publisher: Biomed central ltd
Series Title: Bmc cancer vol:10 pages:-
Abstract: Background: The potential anti-cancer effects of mammalian target of rapamycin (mTOR) inhibitors are being intensively studied. To date, however, few randomised clinical trials (RCT) have been performed to demonstrate antineoplastic effects in the pure oncology setting, and at present, no oncology endpoint-directed RCT has been reported in the high-malignancy risk population of immunosuppressed transplant recipients. Interestingly, since mTOR inhibitors have both immunosuppressive and anti-cancer effects, they have the potential to simultaneously protect against immunologic graft loss and tumour development. Therefore, we designed a prospective RCT to determine if the mTOR inhibitor sirolimus can improve hepatocellular carcinoma (HCC)-free patient survival in liver transplant (LT) recipients with a pre-transplant diagnosis of HCC.
ISSN: 1471-2407
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Abdominal Transplantation
Laboratory of Nephrology
× corresponding author
# (joint) last author

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