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Title: Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group
Authors: De Pauw, Ben ×
Walsh, Thomas J
Donnelly, J Peter
Stevens, David A
Edwards, John E
Calandra, Thierry
Pappas, Peter G
Maertens, Johan
Lortholary, Olivier
Kauffman, Carol A
Denning, David W
Patterson, Thomas F
Maschmeyer, Georg
Bille, Jacques
Dismukes, William E
Herbrecht, Raoul
Hope, William W
Kibbler, Christopher C
Kullberg, Bart Jan
Marr, Kieren A
Muñoz, Patricia
Odds, Frank C
Perfect, John R
Restrepo, Angela
Ruhnke, Markus
Segal, Brahm H
Sobel, Jack D
Sorrell, Tania C
Viscoli, Claudio
Wingard, John R
Zaoutis, Theoklis
Bennett, John E #
Issue Date: Jun-2008
Publisher: The University of Chicago Press
Series Title: Clinical Infectious Diseases vol:46 issue:12 pages:1813-1821
Abstract: BACKGROUND: Invasive fungal diseases are important causes of morbidity and mortality. Clarity and uniformity in defining these infections are important factors in improving the quality of clinical studies. A standard set of definitions strengthens the consistency and reproducibility of such studies. METHODS: After the introduction of the original European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group definitions, advances in diagnostic technology and the recognition of areas in need of improvement led to a revision of this document. The revision process started with a meeting of participants in 2003, to decide on the process and to draft the proposal. This was followed by several rounds of consultation until a final draft was approved in 2005. This was made available for 6 months to allow public comment, and then the manuscript was prepared and approved. RESULTS: The revised definitions retain the original classifications of "proven," "probable," and "possible" invasive fungal disease, but the definition of "probable" has been expanded, whereas the scope of the category "possible" has been diminished. The category of proven invasive fungal disease can apply to any patient, regardless of whether the patient is immunocompromised, whereas the probable and possible categories are proposed for immunocompromised patients only. CONCLUSIONS: These revised definitions of invasive fungal disease are intended to advance clinical and epidemiological research and may serve as a useful model for defining other infections in high-risk patients.
URI: 
ISSN: 1058-4838
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hematology Section (-)
× corresponding author
# (joint) last author

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