Title: Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer consensus criteria
Authors: Segal, Brahm H ×
Herbrecht, Raoul
Stevens, David A
Ostrosky-Zeichner, Luis
Sobel, Jack
Viscoli, Claudio
Walsh, Thomas J
Maertens, Johan
Patterson, Thomas F
Perfect, John R
Dupont, Bertrand
Wingard, John R
Calandra, Thierry
Kauffman, Carol A
Graybill, John R
Baden, Lindsey R
Pappas, Peter G
Bennett, John E
Kontoyiannis, Dimitrios P
Cordonnier, Catherine
Viviani, Maria Anna
Bille, Jacques
Almyroudis, Nikolaos G
Wheat, L Joseph
Graninger, Wolfgang
Bow, Eric J
Holland, Steven M
Kullberg, Bart-Jan
Dismukes, William E
De Pauw, Ben E #
Issue Date: Sep-2008
Publisher: The University of Chicago Press
Series Title: Clinical Infectious Diseases vol:47 issue:5 pages:674-683
Abstract: Invasive fungal diseases (IFDs) have become major causes of morbidity and mortality among highly immunocompromised patients. Authoritative consensus criteria to diagnose IFD have been useful in establishing eligibility criteria for antifungal trials. There is an important need for generation of consensus definitions of outcomes of IFD that will form a standard for evaluating treatment success and failure in clinical trials. Therefore, an expert international panel consisting of the Mycoses Study Group and the European Organization for Research and Treatment of Cancer was convened to propose guidelines for assessing treatment responses in clinical trials of IFDs and for defining study outcomes. Major fungal diseases that are discussed include invasive disease due to Candida species, Aspergillus species and other molds, Cryptococcus neoformans, Histoplasma capsulatum, and Coccidioides immitis. We also discuss potential pitfalls in assessing outcome, such as conflicting clinical, radiological, and/or mycological data and gaps in knowledge.
ISSN: 1058-4838
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hematology Section (-)
× corresponding author
# (joint) last author

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