Title: Bacteraemia in febrile neutropenic cancer patients
Authors: Klastersky, J ×
Ameye, Lieveke
Maertens, Jan
Georgala, A
Muanza, F
Aoun, M
Ferrant, A
Rapoport, B
Rolston, K
Paesmans, M #
Issue Date: Nov-2007
Publisher: Elsevier Science Publishers
Series Title: International Journal of Antimicrobial Agents vol:30 issue:Suppl.1 pages:S51-S59
Abstract: A total of 2142 patients with febrile neutropenia resulting from cancer chemotherapy were registered in two observational studies and followed prospectively in different institutions. There were 499 (23%) patients with bacteraemia who are reviewed here. The relative frequencies of Gram-positive, Gram-negative and polymicrobial bacteraemias were 57%, 34% and 10% with respective mortality rates of 5%, 18% and 13%. Mortality rates were significantly higher in bacteraemic patients than in non-bacteraemic patients; a trend for higher mortality was observed (without reaching statistical significance) in those patients in whom bacteraemia was associated with a clinical site of infection compared to bacteraemic patients without any clinical documentation. Prophylactic antibiotics but not granulopoiesis stimulating factors were associated with a lower incidence of Gram-negative bacteraemia; however, neither prophylactic approach influenced the subsequent rate of complications in the patients who developed bacteraemia. The present study also confirms that the MASCC scoring system can identify a group of bacteraemic patients with a relatively low risk of complications and death (MASCC >/=21). On the other hand, in patients with very low levels of the MASCC score (<15), and then with predicted very unfavourable risk, the rate of complications and death was dramatically high, irrespective of the microbiological nature of the bacteraemia.
ISSN: 0924-8579
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hematology Section (-)
ESAT - STADIUS, Stadius Centre for Dynamical Systems, Signal Processing and Data Analytics
Department of Civil Engineering - miscellaneous
× corresponding author
# (joint) last author

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