Title: Reduced intensity conditioning allogeneic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation
Authors: Mohty, Mohamad ×
Labopin, Myriam
Tabrizzi, Reza
Theorin, Niklas
Fauser, Axel A
Rambaldi, Alessandro
Maertens, Johan
Slavin, Shimon
Majolino, Ignazio
Nagler, Arnon
Blaise, Didier
Rocha, Vanderson #
Issue Date: Feb-2008
Publisher: Il Pensiero Scientifico
Series Title: Haematologica vol:93 issue:2 pages:303-306
Abstract: This retrospective study reported the outcome of 97 adult acute lymphoblastic leukemia patients who received a reduced-intensity conditioning allogeneic stem cell transplantation. With a median follow-up of 2.8 years, two year overall-survival, leukemia-free survival and non-relapse mortality were significantly better in patients transplanted in first complete remission (CR1, 52+/-9%; 42+/-10%; and 18+/-7% respectively) compared with those transplanted in more advanced phase (p=0.003, p=0.002 and p=0.01 respectively). In multivariate analysis, disease status (CR1 vs. advanced; p=0.001) and chronic graft-vs-host disease (p=0.01) were associated with an improved overall-survival, suggesting that reduced-intensity conditioning allogeneic stem cell transplantation is feasible in patients with high risk lymphoblastic leukemia in remission at transplantation.
ISSN: 0390-6078
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hematology Section (-)
× corresponding author
# (joint) last author

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