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Title: Follow-up of men with an elevated PCA3 score and a negative biopsy: does an elevated PCA3 score indeed predict the presence of prostate cancer?
Authors: Remzi, Mesut ×
Haese, Alexander
Van Poppel, Hendrik
de la Taille, Alexandre
Stenzl, Arnulf
Hennenlotter, Jörg
Marberger, Michael #
Issue Date: Oct-2010
Publisher: Blackwell Science
Series Title: BJU International vol:106 issue:8 pages:1138-1142
Abstract: Study Type - Diagnosis (exploratory cohort) Level of Evidence 2b OBJECTIVE To describe the follow-up of men with an elevated 'Prostate CAncer gene 3' (PCA3, a promising novel tool for prostate cancer detection) and a negative repeat biopsy (Bx-), as a previous study in men with one or two negative Bx (Bx-) scheduled for repeat Bx showed that a higher PCA3 score corresponded with a higher probability of a positive repeat Bx (Bx+). PATIENTS AND METHODS This study comprised an analysis of the follow-up of men with a PCA3 score of >/=20 and a repeat Bx-, after which a follow-up Bx was taken. The initial study data in 463 men were also analysed to compare characteristics of: (i) men with a PCA3 score of >/=20 and >/=35 and a repeat Bx+, vs those with a Bx-; and (ii) men with a repeat Bx- and a PCA3 score of >/=20 vs <20 and a PCA3 score of >/=35 vs <35. RESULTS A follow-up Bx was taken in 51 selected men; the Bx+ rate was 55%. Men with a follow-up Bx+ had a higher PCA3 score (mean 69.5, median 50.4) than those with a Bx- (mean 37.7, median 28.2; P < 0.001). They also more often had high-grade prostatic intraepithelial neoplasia (HGPIN) at the previous Bx (46% vs 17%; P= 0.029). Men with a PCA3 score of >/=35 and a repeat Bx+ had a higher PCA3 score (mean 113.9, median 75.7) than those with a Bx- (mean 87.3, median 56.9; P= 0.047). Men with a repeat Bx- and an elevated/high PCA3 score more often had HGPIN than men with a low PCA3 score. CONCLUSIONS An elevated/high PCA3 score can predict prostate cancer in men with one or two previous Bx-. If the repeat Bx is negative, an elevated/high PCA3 score combined with HGPIN might predict prostate cancer at the follow-up Bx.
URI: 
ISSN: 1464-4096
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Urology Section (-)
× corresponding author
# (joint) last author

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