Title: Type 1 cannabinoid receptor mapping with [(18)F]MK-9470 PET in the rat brain after quinolinic acid lesion: a comparison to dopamine receptors and glucose metabolism
Authors: Casteels, Cindy
Martinez, E
Bormans, Guy
Camon, L
de Vera, N
Baekelandt, Veerle
Planas, A
Van Laere, Koen # ×
Issue Date: Dec-2010
Series Title: European Journal of Nuclear Medicine and Molecular Imaging vol:37 issue:12 pages:2354-2363
Article number: 10.1007/s00259-010-1574-2
Abstract: Several lines of evidence imply early alterations in metabolic, dopaminergic and endocannabinoid neurotransmission in Huntington's disease (HD). Using [18F]MK-9470 and small animal PET, we investigated cerebral changes in type 1 cannabinoid (CB1) receptor binding in the quinolinic acid (QA) rat model of HD in relation to glucose metabolism, dopamine D2 receptor availability and amphetamine-induced turning behaviour.
ISSN: 1619-7070
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group for Neurobiology and Gene Therapy
Radiopharmaceutical Research
Nuclear Medicine & Molecular Imaging
× corresponding author
# (joint) last author

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