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Title: Evidence for a positive role of PtdIns5P in T-cell signal transduction pathways
Authors: Guittard, Geoffrey
Mortier, Eva
Tronchere, Helene
Firaguay, Guylene
Gerard, Audrey
Zimmermann, Pascale
Payrastre, Bernard
Nunes, Jacques A # ×
Issue Date: Jun-2010
Publisher: Elsevier on behalf of the Federation of European Biochemical Societies
Series Title: FEBS Letters vol:584 issue:11 pages:2455-2460
Abstract: Phosphatidylinositol 5-phosphate (PtdIns5P) is emerging as a potential lipid messenger involved in several cell types, from plants to mammals. Expression of IpgD, a PtdIns(4, 5)P-2 4-phosphatase induces Src kinase and Akt, but not ERK activation and enhances interleukin II promoter activity in T-cells. Expression of a new PtdIns5P interacting domain blocks IpgD-induced T-cell activation and selective signaling molecules downstream of TCR triggering. Altogether, these data suggest that PtdIns5P may play a sensor function in setting the threshold of T-cell activation and contributing to maintain T-cell homeostasis. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
URI: 
ISSN: 0014-5793
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Signal Integration in Cell Fate Decision
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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