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Title: Long-term cyclosporin A pharmacokinetic profiles in pediatric renal transplant recipients
Authors: Kelles, A ×
Lombaerts, Rita
Tjandra-Maga, Tikma Budya
Van Damme, B #
Issue Date: Jan-1996
Series Title: Transplant International vol:9 issue:6 pages:546-50
Abstract: To study the long-term effect of cyclosporin A (CyA), 94 6-h and 29 12-h pharmacokinetic profiles were evaluated in 32 children at least 1 year after renal transplantation. Children weighing less than 25 kg needed significantly higher doses of CyA than those weighing more than 25 kg (9.8 vs 5.3 mg/kg per day; P < 0.001) to achieve similar trough levels (TL). The average dose of CyA required to achieve the target TL declined gradually with time after transplantation. The average area under the curve over 6 h (AUC/6) correlated strongly with the AUC/12 (r = 0.967; P < 0.001). The AUC/6 of patients with biopsy-proven CyA toxicity was significantly higher than for those without toxicity (Mann-Whitney U-test P < 0.05) despite similar TL. We conclude that AUC monitoring for 6 h provides valuable information not only on TL but also on the absorption and elimination characteristics of CyA as well as on the potential for CyA toxicity.
ISSN: 0934-0874
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmacology Section (-)
Translational Cell & Tissue Research
Laboratory of Pediatric Immunology
× corresponding author
# (joint) last author

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