Title: High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patients
Authors: Barjesteh van Waalwijk van Doorn-Khosrovani, Sahar ×
Erpelinck, Claudia
van Putten, Wim L J
Valk, Peter J M
van der Poel-van de Luytgaarde, Sonja
Hack, Ronald
Slater, Rosalyn
Smit, Elisabeth M E
Beverloo, H Berna
Verhoef, Gregor
Verdonck, Leo F
Ossenkoppele, Gert J
Sonneveld, Pieter
de Greef, Georgine E
Löwenberg, Bob
Delwel, Ruud #
Issue Date: Feb-2003
Series Title: Blood vol:101 issue:3 pages:837-45
Abstract: The proto-oncogene EVI1 encodes a DNA binding protein and is located on chromosome 3q26. The gene is aberrantly expressed in acute myeloid leukemia (AML) patients carrying 3q26 abnormalities. Two mRNAs are transcribed from this locus: EVI1 and a fusion of EVI1 with MDS1 (MDS1-EVI1), a gene located 5' of EVI1. The purpose of this study was to investigate which of the 2 gene products is involved in transformation in human AML. To discriminate between EVI1 and MDS1-EVI1 transcripts, distinct real-time quantitative polymerase chain reaction (PCR) assays were developed. Patients with 3q26 abnormalities often showed high EVI1 and MDS1-EVI1 expression. In a cohort of 319 AML patients, 4 subgroups could be distinguished: EVI1(+) and MDS1-EVI1(-) (6 patients; group I), EVI1(+) and MDS1-EVI1(+) (26 patients; group II), EVI1(-) and MDS1-EVI1(+) (12 patients; group III), and EVI1(-) and MDS1-EVI1(-) (275 patients; group IV). The only 4 patients with a 3q26 aberration belonged to groups I and II. Interestingly, high EVI1 and not MDS1-EVI1 expression was associated with unfavorable karyotypes (eg, -7/7q-) or complex karyotypes. Moreover, a significant correlation was observed between EVI1 expression and 11q23 aberrations (mixed lineage leukemia [MLL] gene involvement). Patients from groups I and II had significantly shorter overall and event-free survival than patients in groups III and IV. Our data demonstrate that high EVI1 expression is an independent poor prognostic marker within the intermediate- risk karyotypic group.
ISSN: 0006-4971
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hematology Section (-)
× corresponding author
# (joint) last author

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