Title: Alzheimer's disease neurons fail the acid test
Authors: Annaert, Wim
De Strooper, Bart # ×
Issue Date: Jun-2010
Publisher: MIT Press
Series Title: Cell vol:141 issue:7 pages:1112-4
Abstract: Mutations in the presenilin genes are the most common cause of familial forms of Alzheimer's disease. Although it is well known for its role in the generation of amyloid peptide, Lee et al. (2010) now report that presenilin 1 deficiency also impacts maturation of the lysosomal proton pump, affecting autophagocytosis and protein turnover.
ISSN: 0092-8674
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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